2026年04月02日
Nature Biotechnology, Published online: 01 April 2026; doi:10.1038/s41587-026-03051-1
ERAST speeds up homology search and provides a vector database for 1 billion biological sequences. 查看全文 →Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03068-6
Simultaneous profiling of adenylated and non-adenylated RNAs reveals regulatory programs across diverse cell types. 查看全文 →Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03083-7
Single-molecule 4Pi microscopy is simplified and made accessible by using a single objective. 查看全文 →Nature Biotechnology, Published online: 30 March 2026; doi:10.1038/s41587-026-03060-0
Non-transgenic crop improvement via cis-regulatory editing is limited by rare activating alleles and incomplete promoter maps. A massively parallel reporter assay in sorghum protoplasts quantifies more than 30,000 CRISPR-mimicking variants across three photosynthesis genes, finely mapping cis-regulatory modules and pinpointing compact edits 查看全文 →Nature Biotechnology, Published online: 30 March 2026; doi:10.1038/s41587-026-03104-5
Immune cell engagers (ICEs) have emerged as a promising strategy for cancer immunotherapy, but their efficacy in solid tumors remains limited, partly as a result of the difficulty of coordinating activating and inhibitory signals within the same immune cell. Here, we report a logic-gated cis-targeting strategy that enables ICEs to coordinate 查看全文 →Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03074-8
Unpaired data as a first-order challenge in single-cell and spatial proteomics 查看全文 →Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03046-y
Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression. 查看全文 →Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03053-z
A long-read metagenome assembly method recovers circular and complete genomes better than existing tools. 查看全文 →Nature, Published online: 02 April 2026; doi:10.1038/d41586-026-01000-1
Study of more than 11,000 women found that only a few hours of moderate-to-vigorous activity per week had a strong effect. 查看全文 →Nature, Published online: 02 April 2026; doi:10.1038/d41586-026-00551-7
Putting off an important task in a long to-do list might be because you fear failure. Or maybe it is success that scares you? 查看全文 →